Table 2.
Cell behaviors and regulatory signals explicitly represented in the virtual palate mode
Behavior | ↑ or ↓ Regulated By |
---|---|
Growth and Proliferation | ↑ contact with Mesench;
BMP2 ↓ Noggin(i)* |
Apoptosis | ↓ contact with any cell or ECM |
ECM Production | ↑ contact with Mesench; BMP2 ↓ Noggin(i) |
Secretion of FGF10 | ↑ contact with Mesench; SHH |
Secretion of BMP2 | ↑ contact with Mesench; SHH |
Secretion of BMP4 | ↑ contact with Mesench;
BMP4 ↓ SHH; Noggin(i) |
Secretion of MMPs | -- |
Secretion of FGF7 | ↑ FGF7 ↓ SHH |
Growth and Proliferation | ↑ FGF10; FGF7; EGF ↓ TGFβ3 |
Apoptosis | ↑ TGFβ3 ↓ contact with any cell or ECM; contact w/ Medium or Peri; EGF |
Differentiation to Mesench. | ↑ contact w/ Mesench or ECM;
TGFβ3 ↓ contact w/ Medium or Peri; EGF |
Differentiation to Periderm | ↑ contact w/ Medium |
BM Production/Maintenance | ↑ contact w/ Mesench or
ECM ↓ MMPs |
Secretion of MMPs | ↑TGFβ3 |
Secretion of SHH | ↑ FGF10; BMP4 ↓ FGF7; Noggin(i) |
Secretion of TGFβ3 | ↓ EGF |
Secretion of EGF | ↓ TGFβ3 |
Secretion of Noggin | -- |
Growth and Proliferation | ↑ FGF10; FGF7; EGF ↓ TGFβ3 |
Apoptosis | ↑ TGFβ3 ↓ contact with any cell or ECM; contact w/ Medium or Peri; EGF |
Polarization | -- |
Motility | ↑ TGFβ3 ↓ EGF |
Secretion of SHH | ↑ FGF10; BMP4 ↓ FGF7; Noggin(i) |
Secretion of TGFβ3 | ↓ EGF |
Secretion of EGF | ↓ TGFβ3 |
Noggin(i) refers to indirect regulation (i) by Noggin binding to BMP2 or BMP4 preventing activation of the BMP receptor as coded in the model.