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. Author manuscript; available in PMC: 2018 Oct 22.
Published in final edited form as: Chem Res Toxicol. 2017 Jan 20;30(4):965–979. doi: 10.1021/acs.chemrestox.6b00350

Table 4.

Palatal Fusion Outcomes from Simulated Exposures.

Exposure model Hysteresis switch Max EGFR fold-change # fused cases n (%-fused) # partially fused n (%-fused) # unfused cases n (%-fused)
constant low 1.10x 15 (100%) 0 0
1.15x 15 (100%) 0 0
1.20x 0 0 21 (100%)
≥1.30x 0 0 3 (100%)
constant high 1.0x 15 (100%) 0 0
1.2x 2 (17%) 9 (75%) 1 (8%)
1.3x 0 0 5 (100%)
1.4x 0 0 15 (100%)
transient low 1.2x 6 (100%) 0 0
1.3x 8 (100%) 0 0
1.6x 2 (100%) 0 0
1.8x 8 (100%) 0 0
transient high 1.2x 4 (100%)* 0 0
1.3x 3 (100%)* 0 0
1.6x 0 1 (25%) 3 (75%)
1.8x 0 0 4 (100%)
*

minor indentations noted

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