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The location of L145 in the SULT1B1 crystal structure (PDBID: 3CKL). L145 is located at the end of α-helix 8 which forms the base of the enzyme’s active site. L145 is adjacent to M146, which forms a key hydrogen bond with D250, anchoring Loop 3 to the active site’s base. Loop 3 overlays both the substrate (left) and PAP (right) binding domains and has key contacts with both the substrate and the cofactor.
