FIG. 7.

Regional plots of paired-pulse (PP) ratio values at 100 msec indicate acute and chronic time-point pericontusional hyperexcitability. (A) Stylized figures showing the position of the two electrode montages used in the experiments in the contralesional (right) cortex, homotopic to the contusion site (blue circle). (B) Plot of pre-injury normalized PP ratio values at 100 msec ISI for all electrode pairs averages across rat, and for the two electrode schemes (S1, S2; corresponding to white, black numbers in A, respectively) demonstrating regional differences in the degree of hyperexcitability that contribute to the mean data (black bar) as originally plotted in Figure 5. Two electrode pairs did not respond to the stimulus (green lines, S2- e3-5, S2-e4-2). (C) Data in (B) plotted spatially and as a percentage of pre-injury values to demonstrate the robust lateral and posterior increases in PP ratio at 3 days and 4 weeks, but largely normal/pre-injury values intermediate times. (D) Summary brain surface atlas superimposed with electrode positions for direct comparisons to data in (C).