Table 1.
Characteristics of self-reported white participants with genetic data available included in the ACCORD trial
| Characteristic | All participants | GRS tertile |
|||
|---|---|---|---|---|---|
| Low risk | Intermediate risk | High risk | P | ||
|
N |
5,360 |
1,787 |
1,786 |
1,787 |
|
| Age (years) |
62.8 ± 6.5 |
63.2 ± 6.4 |
62.8 ± 6.5 |
62.3 ± 6.5 |
0.0003 |
| Female |
1,888 (35.2) |
626 (35.0) |
636 (35.6) |
626 (35.0) |
0.9 |
| Ever smoker |
3,348 (62.5) |
1,097 (61.4) |
1,138 (63.7) |
1,113 (62.3) |
0.3 |
| BMI (kg/m2) |
33.0 ± 5.2 |
33.1 ± 5.1 |
32.9 ± 5.2 |
32.9 ± 5.2 |
0.5 |
| Duration of diabetes (years) |
10.7 ± 7.5 |
10.7 ± 7.4 |
10.9 ± 7.6 |
10.5 ± 7.3 |
0.3 |
| Baseline HbA1c (%) |
8.2 ± 1.0 |
8.24 ± 0.95 |
8.19 ± 0.96 |
8.21 ± 0.95 |
0.4 |
| Fasting plasma glucose (mg/dL) |
178.5 ± 50.9 |
179.2 ± 52.0 |
178.3 ± 49.8 |
178.0 ± 50.9 |
0.8 |
| HDL cholesterol (mg/dL) |
40.3 ± 10.3 |
40.7 ± 10.4 |
40.5 ± 10.5 |
39.6 ± 9.9 |
0.005 |
| Total cholesterol (mg/dL) |
183.0 ± 40.0 |
182.8 ± 39.5 |
182.3 ± 40.1 |
183.9 ± 40.4 |
0.5 |
| LDL cholesterol (mg/dL) |
102.9 ± 32.3 |
102.4 ± 31.9 |
102.2 ± 32.2 |
104.2 ± 32.7 |
0.11 |
| Triglycerides (mg/dL) |
203.7 ± 122.3 |
203.2 ± 120.6 |
201.5 ± 121.0 |
206.4 ± 125.2 |
0.5 |
| Statin treatment |
3,425 (64.1) |
1,070 (60.0) |
1,147 (64.4) |
1,208 (67.9) |
<0.0001 |
| Systolic BP (mmHg) |
135.2 ± 16.5 |
135.4 ± 16.6 |
135.0 ± 16.4 |
135.2 ± 16.5 |
0.8 |
| Diastolic BP (mmHg) |
74.1 ± 10.2 |
74.3 ± 10.3 |
74.0 ± 10.2 |
74.0 ± 10.2 |
0.6 |
| BP medication |
4,419 (82.4) |
1,454 (81.4) |
1,477 (82.7) |
1,488 (83.3) |
0.3 |
| Creatinine (mg/dL) |
0.90 ± 0.22 |
0.91 ± 0.22 |
0.91 ± 0.22 |
0.90 ± 0.22 |
0.3 |
| Glomerular filtration rate (mL/min/1.7 m2) |
88.1 ± 21.6 |
87.4 ± 21.1 |
87.8 ± 21.6 |
89.2 ± 22.1 |
0.04 |
| Family history of CVD |
2,629 (50.6) |
826 (47.8) |
858 (49.5) |
945 (54.7) |
0.0001 |
| History of CAD |
1,643 (30.7) |
429 (24.0) |
531 (29.7) |
683 (38.2) |
<0.0001 |
| Rescaled weighted GRS |
187.4 ± 8.1 |
178.6 ± 4.1 |
187.4 ± 2.0 |
196.3 ± 4.4 |
N/A |
| Standardized GRS | 0.0 ± 1.0 | –1.1 ± 0.5 | 0.0 ± 0.2 | 1.1 ± 0.5 | N/A |
Data are mean ± SD or n (%) unless otherwise noted. To convert the values for glucose to millimoles per liter, multiply by 0.05551. To convert the values for cholesterol to millimoles per liter, multiply by 0.02586. To convert the values for triglycerides to millimoles per liter, multiply by 0.01129. To convert the values for creatinine to micromoles per liter, multiply by 88.4. P values for comparison across tertiles were calculated based on ANOVA or χ2 test. BP, blood pressure; CVD, cardiovascular disease; N/A, not applicable.