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. 2018 Oct 8;2018:3939714. doi: 10.1155/2018/3939714

Figure 4.

Figure 4

Momordicine I increases Nrf2 translocation and HO-1 protein expression in rat cardiac fibroblasts. (a) Effect of momordicine I on Nrf2 translocation. Cells were treated with or without momordicine I (1 μM) for 12 h, followed by a normal-glucose medium or high-glucose medium for 12 h. N: nuclear extract. Results are presented as the mean ± SEM (n = 4). (b) HO-1 expression was determined through Western blotting. Cells were pretreated with momordicine I (1 μM) or not for 12 h, followed by the control medium or high-glucose medium for 24 h. Results are presented as the mean ± SEM (n = 3). The relative protein expression of nuclear Nrf2 to PARP and HO-1 to GAPDH are presented in the bar graphs. ∗P < 0.05 versus the control group; #P < 0.05 versus the high-glucose group.