Table 4.
Synthetic antispasmodic compounds used in medicine.
| Synthetic compound | Receptor targeted | Main use |
|---|---|---|
| Alkaloids | ||
| Chlorzoxazone | Prevents release of histamine | Muscular spasm |
| Pancuronium | Nicotinic acetylcholine | Muscle relaxant |
| Riluzole | Sodium channels | Amyotrophic lateral sclerosis |
| Rocuronium | Antagonist of neuromuscular junction | Muscle relaxant and anaesthesia |
| Tizanidine | α 2 adrenergic agonist | Muscle relaxant |
| Vecuronium | Nicotinic acetylcholine | Muscle relaxant and anaesthesia |
|
| ||
| Curcuminoids | ||
| Atracurium | Nicotinic acetylcholine | Muscle relaxant and anaesthesia |
| Cisatracurium | Nicotinic acetylcholine | Muscle relaxant and anaesthesia |
| Mivacurium | Nicotinic acetylcholine | Muscle relaxant and anaesthesia |
|
| ||
| Methylpropanoid | ||
| Diazepam | GABAA | Anxiety, alcohol withdrawal syndrome, muscle spasms, seizures, and restless legs syndrome |
| Prograbide | GABAA+B | Epilepsy |
| Orphenadrine | Skeletal muscle relaxant that is used for the treatment of acute muscle aches, pain, or spasms. | |
|
| ||
| Phenylpropanoids | ||
| Baclofen | GABAB | Spinal cord injury, cerebral palsy, and multiple sclerosis |
| Idrocilamide | Prevents release of intracellular Ca2+ | Skeletal muscle relaxant and muscular pain |