Table 1.
Substrate scope of the photoenzymatic decarboxylation reaction.[a]
| Substrate | [Product] [mm] | Conversion [%][b] | TON (CvFAP)[c] |
|---|---|---|---|
| C12H24O2
(lauric acid) |
3.0 | 11 | 500 |
| C14H28O2
(myristic acid) |
6.9 | 25 | 1150 |
| C16H32O2
(palmitic acid) |
27.7 | 96 | 4610 |
| C17H34O2
(margaric acid) |
28.7 | 96 | 4780 |
| C18H36O2
(stearic acid) |
26.1 | 92 | 4350 |
| C18H34O2 (Δ9) (oleic acid) |
17.7 | 65[d] | 2950 |
| C18H32O2 (Δ9, 12) (linoleic acid) |
14.6[c] | 49[d] | 2600 |
| C20H40O2
(arachidic acid) |
25.7 | 90 | 4580 |
[a] Reaction conditions: [substrate]=30 mm, [CvFAP]=6.0 μm, Tris‐HCl buffer (pH 8.5, 100 mm), 30 % DMSO, illumination with blue light (intensity=13.7 μE L−1 s−1) for 14 h. [b] Conversion: [product]final×([product]final+[substrate]final)−1. [c] TON: [product]final×[CvFAP]−1. [d] Due to the lack of a standard reference, the conversion was calculated by using: conversion=([substrate]initial− [substrate]final)×[substrate]initial −1.