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. Author manuscript; available in PMC: 2019 Jan 4.
Published in final edited form as: Nature. 2018 Jul 4;560(7719):499–503. doi: 10.1038/s41586-018-0343-4

EF6: Impact of Copanilisib with or without ketogenic diet upon growth of KPC tumor model K8082 grown in the flank of wildtype c57/bl6 mice.

EF6:

(A) Survival curves for mice with KPC K8082 allografts grown in the flank and treated as indicated with BAY 80–6946 alone and in combination with pretreatment with a ketogenic diet as indicated (p-value comparing BAY 80–6946 to the combination of BAY 80–6946 with ketogenic diet in this study is 0.0019 by Mantel-Cox Log-rank test). N= 5 mice/arm in the Vehicle, Bay 80–6946, and Bay 80–6946 + Ketogenic Diet arms, and N = 4 in the ketogenic diet alone arm. (B) Curves of the volume each tumor in this cohort graphed as individual lines. (C) Mean blood glucose and (D) c-peptide measurements with standard deviation taken from the animals in B-C 240 min after treatment. (F) Graph of the mass of these animals over time on treatment. Tumors were allowed to grow until their diameters were >0.6cm prior to the initiation of treatment.