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. Author manuscript; available in PMC: 2019 Jan 4.
Published in final edited form as: Nature. 2018 Jul 4;560(7719):499–503. doi: 10.1038/s41586-018-0343-4

Figure 2: Impact of feedback levels of insulin on cellular proliferation, signaling and survival.

Figure 2:

(A) Western blot analysis of KPC cell lines K8484 and K8082 treated with or without PI3K inhibitor BKM120 (1uM) in the presence or absence of physiologic feedback levels of insulin (10ng/ml). Similar results were observed in three independent experiments. (B-C) Mean confluence with standard deviation of KPC cell lines K8484 and K8082 over time grown in the presence or absence of insulin (10ng/ml) and BKM120 (1uM). p-values determined by ANOVA comparing conditions +/− insulin are shown, N=16 biologically independent samples per group.