Table 1.
An overview in mouse of the contribution of the iNKT cell/IL-33 biological axis during acute sterile inflammation.
| Reference(s) | Model | Organ | Role of iNKT cells | Mode of action of iNKT cells | Role of IL-33 | iNKT cell/IL-33 axis |
|---|---|---|---|---|---|---|
| Ferhat et al. (7) Li et al. (8) |
IRI | Kidney | initiation (7, 8) Jα18 KO mice |
IFN-γ, IL-17 CD1d-dependent |
Initiation (7) IL-33 KO mice ST2 KO mice |
IL-33-dependent iNKT cell recruitment/activation (7) |
| Lappas et al. (11) Arrenberg et al. (12) Richards et al. (16) Kuboki et al. (17) Yazdani et al. (18) |
IRI | Liver | initiation (11, 12, 16, 17) NK1.1 depletion iNKT-cell adoptive transfer |
IFN-γ, IL-17 CD1d-dependent |
Initiation (18) IL-33 KO mice |
Presumably yes |
| Arshad et al. (19) Arshad et al. (20) |
ConA-induced injury | Liver | initiation (19, 20) iNKT-cell adoptive transfer |
IL-4, IFN-γ | Resolution (20) | iNKT-cell-dependent regulation of IL-33 expression by hepatocytes |
| Cao et al. (21) | IRI | Liver | resolution (21) by iNKT-cell-targeted therapy (α-GalCer) |
IL-13 A2AR |
Unknown | Unpredictable |
| Lappas et al. (11) | IRI | Liver | resolution (11) by iNKT-cell-targeted therapy (A2AR agonist) |
IFN-γ ↓ | unknown | Presumably not |
| Cheng et al. (22) Antunes et al. (23) |
Drug-induced injury | Liver | initiation (22) CD1d KO mice |
Not done | Initiation (23) ST2 KO mice |
Presumably yes |
| Liew et al. (24) | Thermal injury | Liver | resolution (24) iNKT-cell adoptive transfer |
IL-4 | Unknown | Unpredictable |
| Sharma et al. (13, 25) | IRI | Lung | initiation (13, 25) Jα18 KO mice iNKT-cell adoptive transfer |
NOX-2 IL-17 |
Unknown | Unpredictable |
| Sharma et al. (25) | IRI | Lung | resolution (25) by iNKT-cell-targeted therapy (A2AR agonist) |
NOX-2 ↓ ê IL-17 ↓ |
Unknown | Unpredictable |
| Grabarz et al. (26) Kim et al. (27) Bourgeois et al. (28) Li et al. (29) Luzina et al. (30) |
Bleomycin-induced fibrosis | Lung | resolution (26, 27) | IFN-γ | Initiation (29, 30) | Presumably yes (28) |
| Michaudel et al. (31) Pichavant et al. (32) Kubala et al. (33) |
Ozone-induced fibrosis | Lung | initiation (32) Jα18 KO mice |
IL-17 | Initiation (31, 33) resolution (31) IL-33 KO mice |
Presumably yes (32) presumably not |
This table recapitulates the main models of acute sterile inflammation, especially IRI models, that involve iNKT cells in different target organs (kidney, liver, and lung). In parallel, when documented, the involvement of IL-33 is indicated; otherwise it is noted as unknown. The implication(s) of iNKT cells and/or IL-33 has (have) been classified according to their contribution to the initiation and/or resolution phase(s) of sterile inflammation, and accompanied by the relevant bibliography. The mode(s) of action of iNKT cells is (are) specified. In the last column, using the cited bibliography, the existence of an iNKT cell/IL-33 axis is shown, surmised (noted ≪ presumably yes ≫) not surmised (noted ≪ presumably not ≫) or difficult to predict (noted ≪ unpredictable ≫). IRI, Ischemia-Reperfusion injury; A2AR, adenosine A2A receptor; α-GalCer, α-galactosylceramide; iNKT, invariant Natural Killer T; KO, transgenic knockout; IFN, interferon; IL, interleukin; NOX-2, NADPH oxidase 2; ↓, decrease.