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. 2018 Oct 22;4:50. doi: 10.1038/s41420-018-0114-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Nuclear condensation and DNA fragmentation by TUNEL-DAPI co-staining (magnification, ×200). b Caspase-3 activity. c Time-course of Hcy on activecaspase-3 expression. d ATX attenuated Hcy-induced PARP cleavage and caspase-3 activation. Details of the experiments were conducted according to the section of methods. Scale bar in figures indicates 30 μm. All data and images were obtained from three random experiments. Bars different letters indicate the statistic difference at P < 0.05