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. 2018 Oct 22;9(11):1076. doi: 10.1038/s41419-018-1117-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Timeline showing the process of establishing the GC heterotopic model. MiR-10a KO KGN or control KGN cells were injected in the back of nude mice, followed by feeding mice with dox to induce CRISPR/Cas9-mediated miR-10a KO. b The size of tumor formed from miR-10a KO KGN cells was smaller in dox-treated group (n = 5). c Histological analysis of the tumors formed from miR-10a KO cancer GC and control cancer GC. d IHC staining showed the expression of tumor suppressor PTEN, P-AKT, and FOXO1 in the miR-10a KO and control tumors