Fig. 2. Hippocampal morphology in Nrg1^{tg-type I} mice.

a Hippocampal volume is increased in Nrg1^{tg-type I} mice (n = 10) compared with wt (n = 9; two-tailed unpaired t test, t = 3.249, df = 17, p = 0.006), but whole brain volume is unchanged. b The width of the dentate gyrus granule cell layer is increased in Nrg1^{tg-type I} mice in the infra-pyramidal blade (n = 6 in each group; two-tailed unpaired t test, t = 4.126, df = 10, p = 0.002) but not in the supra-pyramidal blade. c Illustration of the data in b, showing the wider infra-pyramidal blade (IPB) in a Nrg1^{tg-type I} mouse compared with a wt mouse. The supra-pyramidal blade (SPB) is also shown, with CA3 in between. d The density of parvalbumin (PV)-immunoreactive cells did not differ in Nrg1^{tg-type I} mice (n = 10) compared with wt (n = 12). Bars in a, b, and d show mean and standard deviation. All data in this Figure come from 10-month-old mice