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. 2018 Oct 22;9:4373. doi: 10.1038/s41467-018-06878-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — p62zz is a recognin of Nt-R. a p62/SQSTM domain architecture. b Electrostatic surface potential of p62_ZZ colored blue and red for positive and negative charges, respectively. The bound Nt-R substrate (residues RE) are shown in stick. c A ribbon diagram of the crystal structure of p62_ZZ (wheat) in complex with the Nt-R substrate (green). Dashed lines indicate hydrogen bonds and salt bridges. d Superimposed ¹H,¹⁵N HSQC spectra of p62_{ZZ (115–190)} collected while the REEE peptide was titrated in. Spectra are color coded according to the protein:peptide molar ratio. e Superimposed ¹H,¹⁵N HSQC spectra of p62_{ZZ (115-190)} collected upon titration with the indicated 4-mer peptides. Spectra are color coded according to the protein:peptide molar ratio