Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 22;8:15587. doi: 10.1038/s41598-018-33875-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

TBK1/IKKε inhibition augments β-cell regeneration in a zebrafish model of type 1 diabetes. (A, B, D–H) Bright-field images combined with fluorescent images showing the overall morphology and [Tg(ins:CFP-NTR)^s892; Tg(ins:Kaede)^jh6] expression (green) of larvae at 48 hpa treated with DMSO (A), BX795 (B), BX912 (D), amlexanox (E), AZ-5c (F), AZ-5e (G), and PIAA (H), respectively. While TBK1/IKKε-Is substantially expanded [Tg(ins:CFP-NTR)^s892; Tg(ins:Kaede)^jh6]-expressing cell population (white squares and insets) during regeneration (B and E–H) compared to DMSO (A), the PDPK1 inhibitor BX912 showed minimum effect (D). (C) BX795 is a dual inhibitor of PDPK1 and TBK1/IKKε. (I) Quantification of the number (mean ± SD) of total regenerated β-cells at 48 hpa (in A-B and D-H; 4.3 ± 1.3 (DMSO), 9.0 ± 2.2 (BX795), 4.7 ± 1.2 (BX912), 11.0 ± 3.4 (amlexanox), 7.4 ± 1.4 (AZ-5c), 7.0 ± 1.3 (AZ-5e), and 17.7 ± 2.4 (PIAA)). Cells in 20 planes of confocal images from 25 individual larvae were counted per condition. ***P < 0.001.