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. 2018 Oct 15;10:161–168. doi: 10.2147/BCTT.S170208

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© 2018 Lozano et al. This work is published and licensed by Dove Medical Press Limited

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Nonclassical pattern of TRPV1 identifies higher malignancy breast carcinomas.

Notes: (A) The immunofluorescence of C-TRPV1 and N-TRPV1 antibodies confirmed the expression of TRPV1 in breast cancer, with a diffuse expression pattern. (B) The immunohistochemical detection of TRPV1 shows a classical pattern at the plasma membrane and cytosol, and a nonclassical pattern with aggregates of TRPV1 at the ER/Golgi and/or a relatively diffuse distribution of the channel at the surrounding cytosol. (C) The classical TRPV1 pattern was more frequent in lower malignancy St. Gallen subtypes luminal A + luminal B compared to the most aggressive subtypes Her 2 + triple negative. (D) Survival curves according to the pattern of TRPV1 subcellular distribution.