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. 2018 Oct 22;8:15568. doi: 10.1038/s41598-018-33834-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The plasma concentration (A,B) and urinary elimination (C,D) profiles of compound 1 (A,C) and GA (B,D) and in female SD rats (closed circle) and EHBRs (closed triangle) after oral administration of GA. GA (200 mg/kg) was administered orally to female SD rats or EHBRs, and plasma and urine samples were collected. The concentrations of compound 1 and GA were measured by LC-MS/MS. Data are plotted as mean ± S.E. (n = 4).