Figure 5.

Coefficient parameters of the fitted statistical model. Coefficients for the top 20 active residues, where the activeness of each residue is defined as $s_j:=\sqrt{{\sum }_{i=1}^M{\beta }_{i,j}^2},j=\mathrm{1,}\dots ,N$. Here, red and blue indicate that the corresponding parameters are positive and negative, respectively, whereas grey indicates that the amino-acid species did not exist in the training data. The figure can be interpreted such that, if the value of a coefficient parameter β_i,j is positive/negative (i.e. red/blue), then the existence of the i-th amino-acid species at the j-th residue has a red-shifting/blue-shifting effect.