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. 2018 Oct 22;8:15572. doi: 10.1038/s41598-018-33629-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypomethylation of the EN1 Promoter and Increased EN1 Expression in Basal-like Breast Tumors. (A) Arrows indicate seven CpG sites of the EN1 promoter analyzed. (B) Analysis of TCGA HumanMethylation450 Array data showed significantly lower methylation in seven CpG sites of the EN1 promoter in BLBC tumors compared to normal breast tissues and other subtype breast tumors (p < 0.001). Beta values (0 to 1) are relative values increasing from hypomethylation to hypermethylation. (C, D) EN1 expression is significantly higher in basal like tumors compared to other subtype tumors, both in TCGA (C) and our RNA-seq datasets (D). (E) EN1 expression was analyzed using Pan-Cancer RNA-seq datasets and presented as log₂ (FPKM + 1) values. Abbreviations of tumor types are described in Fig. 2A legend.