Fig. 10.

Summary map of the human liver. The main “building block” of the liver is the hepatic lobule, which includes a portal triad, hepatocytes aligned between a capillary network, and a central vein. The portal triad is made up of the hepatic artery, the portal vein and the bile duct. Found between the liver sinusoids are parenchymal cells (hepatocytes) and non-parenchymal cells (endothelial cells, cholangiocytes, macrophages, hepatic stellate cells, and liver infiltrating lymphocytes- including B cells, αβ and γδ, T cells, and NK cells). Non-inflammatory macrophages are labeled ^∗Kupffer cells based on their transcriptional similarity to mouse KC. The location of B cells, plasma cells, T cells, and NK cells has yet to be confirmed by immunohistochemical staining of these populations in situ so their location in this schematic is not representative of their zonated distribution. The zonation of hepatocytes was not confirmed by immunohistochemical staining and is inferred as a result of pathway analysis and transcriptional similarity to the zonated gene expression patterns previously shown in mice (Halpern et al.¹²)