Fig. 1.

Celastrol attenuated cisplatin-induced acute kidney injury in mice.

(a) Representative images of periodic acid-Schiff staining (×200 and ×400) of kidneys. (b) Tubular injury score in mice. Data were presented as means ± SD of 10 random fields from each kidney. Blood urea nitrogen (c), serum creatinine (d), serum cystatin C (e), and MDA (f) levels were measured. (g) qRT-PCR analyses of renal KIM-1 and NGAL mRNA expression. GAPDH was used as internal control. Data were presented as means ± SD (n = 8 in each group). All experiments were duplicated for three times. Statistically significant differences were determined by one-way ANOVA, ## P < 0.01, ### P < 0.001, * P < 0.05, *** P < 0.001. CP: cisplatin.