Table 2.

Summary effects in the overall, modifier (HWE), and subgroup (tendon/ligament) analyses of COL5A1 with TLI

Comparison [R] genetic model	n	Test of association			Test of heterogeneity
		OR	95% CI	P a	P b	I2 (%)	AM
rs12722 All [26–32]
H	9	0.69	0.54–0.89	0.003	0.25	21	FE
R	9	0.72	0.52–0.99	0.04	0.05	48	RE
D	9	0.90	0.68–1.21	0.49	0.001	69	RE
C	9	0.87	0.69–1.10	0.24	0.0001	75	RE
rs13946 All [26, 30–32]
H	5	0.83	0.33–2.08	0.69	0.006	72	RE
R	5	0.79	0.35–1.78	0.57	0.02	67	RE
D	5	1.12	0.78–1.63	0.54	0.02	65	RE
C	5	1.01	0.76–1.34	0.94	0.03	63	RE
rs12722 HWE [27–32]
H	7	0.68	0.52–0.88	0.004	0.13	39	FE
R	7	0.76	0.53–1.09	0.13	0.04	55	RE
D	7	0.86	0.66–1.12	0.27	0.05	52	RE
C	7	0.88	0.66–1.17	0.37	10−5	79	RE
rs13946 HWE [26, 30–32]
H	4	1.03	0.39–2.72	0.95	0.02	70	RE
R	4	1.00	0.44–2.27	1.00	0.05	61	RE
D	4	1.15	0.72–1.83	0.56	0.01	73	RE
C	4	1.06	0.76–1.46	0.74	0.03	68	RE
rs12722 Tendon [26–28, 31]
H	5	0.87	0.59–1.27	0.46	0.11	47	FE
R	5	0.81	0.42–1.57	0.53	0.009	70	RE
D	5	0.84	0.55–1.29	0.43	0.01	73	RE
C	5	0.98	0.62–1.55	0.95	10−5	86	RE
rs13946 Tendon [26, 31]
H	3	0.70	0.14–3.56	0.66	0.001	85	RE
R	3	0.63	0.16–2.58	0.52	0.005	81	RE
D	3	1.15	0.63–2.12	0.65	0.01	78	RE
C	3	0.97	0.58–1.61	0.90	0.006	81	RE
rs12722 Ligament [29, 30, 32]
H	4	0.59	0.43–0.82	0.001	0.96	0	FE
R	4	0.65	0.49–0.86	0.003	0.80	0	FE
D	4	0.99	0.66–1.50	0.96	0.03	68	RE
C	4	0.77	0.66–0.90	0.0009	0.95	0	FE
rs13946 Ligament [30, 32]
H	2	1.07	0.51–2.26	0.85	0.39	0	FE
R	2	1.10	0.54–2.24	0.80	0.22	34	FE
D	2	1.04	0.74–1.46	0.82	0.16	48	FE
C	2	1.04	0.80–1.35	0.79	0.53	0	FE

Cut-offs for P^a and P^b are < 0.05 and 0.10, respectively. Values in italics indicate significant associations

H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] references, OR odds ratio, CI confidence interval, P^a p value for association, P^b p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RE random-effects