Table 3.

Post-outlier analysis outcomes of the COL5A1 polymorphism associations with TLI

Comparison genetic model	n	[R]	Test of association			Test of heterogeneity			Outlier treatment effect
			OR	95% CI	P a	P b	I2 (%)	AM
rs12722 all
R	8	[26, 27, 29, 31, 32]	0.65	0.52–0.81	0.0002	0.19	30	FE	RH, ES
D	7	[26–29, 31, 32]	0.72	0.61–0.86	0.0003	0.88	0	FE	EH, GS
C	8	[26, 28–32]	0.78	0.69–0.87	0.0001	0.63	0	FE	EH, GS
rs13946 all
H	3	[30, 31]	0.37	0.17–0.82	0.01	0.73	0	FE	EH, GS
R	3	[30, 31]	0.35	0.16–0.77	0.009	0.86	0	FE	EH, GS
D	4	[30–32]	0.95	0.74–1.22	0.69	0.36	8	FE	RH
C	4	[30–32]	0.90	0.74–1.10	0.30	0.36	6	FE	RH
rs12722 HWE
R	6	[27, 29–32]	0.67	0.53–0.86	0.002	0.14	40	FE	RH. GS
D	6	[27–32]	0.76	0.63–0.92	0.004	0.96	0	FE	EH, GS
C	6	[28–32]	0.76	0.66–0.86	10 −5	0.94	0	FE	EH, GS
rs13946 HWE
H	3	[31]	0.73	0.38–1.38	0.33	0.16	46	FE	RH
R	3	[31]	0.77	0.41–1.43	0.40	0.11	55	FE	RH
D	3	[31]	0.93	0.71–1.24	0.64	0.20	37	FE	RH
C	3	[31]	0.92	0.74–1.16	0.49	0.23	32	FE	RH
rs12722 tendon
R	3	[26, 31]	0.45	0.28–0.72	0.0008	0.45	0	FE	EH, GS
D	4	[26–28, 31]	0.66	0.52–0.84	0.0006	0.76	0	FE	EH, GS
C	4	[26–28, 31]	0.78	0.65–0.94	0.008	0.18	38	FE	RH, GS
rs13946 tendon
H	2	[31]	0.32	0.13–0.79	0.01	0.69	0	FE	EH, GS
R	2	[31]	0.32	0.13–0.78	0.01	0.79	0	FE	EH, GS
D	2	[31]	0.85	0.59–1.24	0.40	0.39	0	FE	EH
C	2	[31]	0.75	0.55–1.02	0.06	0.58	0	FE	EH
rs12722 ligament
D	3	[29, 30, 32]	0.8	0.62–1.04	0.10	0.97	0	FE	EH

Cut-offs for P^a and P^b are < 0.05 and 0.10, respectively. Values in italics indicate significant associations

H homozygous, R recessive, D dominant, C codominant, n number of studies, [R] References, OR odds ratio, CI confidence interval, P^a p-value for association, P^b p value for heterogeneity, AM analysis model, HWE Hardy–Weinberg Equilibrium, FE fixed-effects, RH reduced heterogeneity, ES elevated significance, EH eliminated heterogeneity, GS gained significance