Fig 3.

Typical appearance of apoptotic [activated caspase-3 (AC3)-positive] oligodendrocytes (oligos). Shown here are dying oligos in the corpus callosum following a 3 h exposure of the infant non-human primate (NHP) to isoflurane (ISO). These cells have many processes that emanate from the cell body in a radial pattern. Each process has an expanded thin sheet-like foot that is specialized to wrap around axons. As these sheet-like processes degenerate they cause the neuropil surrounding the cell body to have a dark smudgy appearance. Oligo degeneration following ISO exposure occurs diffusely and in an evenly distributed pattern throughout white matter regions of the brain. Bar=25 µm.