Table 2. Baseline Characteristics According to Diffusion Capacity of Carbon Monoxide.
| All Patients (N = 152) |
Patients With DLCO >45% (n = 122) |
Patients With DLCO ≤45% (n = 30) |
p Value | |
|---|---|---|---|---|
| Age, yrs | 70.0 ± 8.1 | 69.3 ± 8.4 | 72.5 ± 6.6 | 0.068 |
| Females | 106 (69.7) | 87 (71.3) | 19 (63.3) | 0.441 |
| Cardiac events | 51 (33.6) | 37 (30.3) | 14 (46.6) | 0.089 |
| Body mass index, kg/m2 | 30.9 ± 6.4 | 31.1 ± 5.9 | 29.9 ± 6.3 | 0.406 |
| 6-MWD, m | 329.5 ± 108.9 | 343.5 ± 102.0 | 275.8 ± 120.1 | 0.005 |
| Tiffeneau index | 74.1 ± 12.1 | 75.4 ± 12.2 | 70.7 ± 10.0 | 0.112 |
| History of smoking | 46 (30.3) | 39 (32.0) | 7 (23.3) | 0.277 |
| LA diameter, mm | 61.8 ± 7.5 | 61.4 ± 7.1 | 63.6 ± 8.3 | 0.205 |
| LV diameter, mm | 43.8 ± 5.3 | 43.8 ± 4.7 | 43.5 ± 7.3 | 0.793 |
| LV function, EF, %* | 64.9 ± 10.8 | 65.4 ± 10.8 | 63.5 ± 10.7 | 0.476 |
| RA diameter, mm | 62.1 ± 8.4 | 61.8 ± 7.7 | 63.1 ± 10.9 | 0.539 |
| RV diameter, mm | 36.6 ± 8.1 | 35.8 ± 7.9 | 40.1 ± 8.1 | 0.022 |
| RV function, EF, %* | 53.7 ± 11.6 | 54.1 ± 11.1 | 52.5 ± 13.5 | 0.577 |
| eGFR, ml/min/1.73 m2 | 60.2 ± 17.5 | 62.0 ± 17.5 | 52.8 ± 15.6 | 0.017 |
| Hematocrit, g/dl | 38.1 ± 4.7 | 38.5 ± 4.7 | 36.2 ± 4.5 | 0.027 |
| NT-proBNP, pg/ml | 1,068 (412–1,727) | 971 (366–1,613) | 1,477 (766–2,447) | 0.005 |
| Systolic PAP, mm Hg | 54.9 ± 17.7 | 52.5 ± 15.9 | 65.5 ± 21.1 | 0.008 |
| Diastolic PAP, mm Hg | 22.4 ± 7.4 | 21.6 ± 6.5 | 25.6 ± 9.8 | 0.017 |
| Mean PAP, mm Hg | 34.9 ± 10.0 | 33.6 ± 8.9 | 40.9 ± 12.6 | 0.020 |
| PAWP, mm Hg | 20.3 ± 5.3 | 20.2 ± 5.3 | 22.7 ± 5.9 | 0.072 |
| LVEDP, mm Hg | 19.8 ± 5.3 | 19.4 ± 5.0 | 19.6 ± 5.3 | 0.830 |
| PAWP-LVEDP, mm Hg | 1.3 ± 4.1 | 0.8 ± 3.8 | 3.1 ± 4.8 | 0.031 |
| RAP, mm Hg | 13.0 ± 5.5 | 12.1 ± 5.4 | 14.5 ± 5.6 | 0.050 |
| Cardiac output, l/min | 5.3 ± 1.4 | 5.4 ± 1.4 | 5.0 ± 1.3 | 0.126 |
| SvO2, % | 64.6 ± 9.0 | 65.8 ± 7.6 | 59.7 ± 12.7 | 0.036 |
| PVR, dyn⋅s⋅cm−5 | 231.6 ± 131.4 | 211.5 ± 95.2 | 318.8 ± 209.4 | 0.028 |
| PAC, ml/mm Hg | 2.7 ± 1.3 | 2.8 ± 1.2 | 2.0 ± 0.9 | 0.005 |
| DPG, mm Hg | 2.1 ± 5.8 | 1.8 ± 5.1 | 3.5 ± 7.9 | 0.198 |
| TPG, mm Hg | 14.7 ± 7.2 | 13.8 ± 6.0 | 18.1 ± 10.3 | 0.059 |
Values are mean ± SD, n (%). All values, except for NT-proBNP (p < 0.001), were distributed normally; therefore medians (interquartile ranges) for NT-pro BNP are presented. Bold indicates p < 0.05. *Measurements were derived from cardiac magnetic resonance imaging (n = 96).
6-MWD = 6-min walk distance; DPG = diastolic pressure gradient; EF = ejection fraction; eGFR = estimated glomerular filtration rate; LA = left atrium; LV = left ventricle; LVEDP = left ventricular end-diastolic pressure; PAC = pulmonary arterial compliance; PAP = pulmonary arterial pressure; PAWP = pulmonary artery wedge pressure; PVR = pulmonary vascular resistance; RA = right atrium; RAP = right atrial pressure; RV = right ventricle; SvO2 = mixed venous oxygen saturation; TPG = transpulmonary pressure gradient.