Table 3. Predictors of death from right heart failure. Univariable and multivariable Cox regression analysis.
| Variable | Event (n = 21) | No event (n = 209) | Hazard ratio | 95% CI | P-value |
|---|---|---|---|---|---|
| Simple regression | |||||
| NYHA functional class | 3.2 ± 0.5 | 2.7 ± 0.59 | 3.55 | 1.70–7.43 | 0.001 |
| 6 –minute walk distance, meters | 223 ± 125 | 325 ± 117 | 0.99 | 0.99–1.00 | 0.001 |
| GFR, mL/min/1.73 m2 | 44.3 ± 14.7 | 61.0 ± 19.9 | 0.96 | 0.94–0.98 | < 0.001 |
| NT-pro BNP, pg/mL | 4596 ± 5887 | 1596 ± 1964 | 1.00 | 1.00–1.00 | < 0.001 |
| Haemoglobin, g/dL | 11.2 ± 2.09 | 12.3 ± 1.8 | 0.63 | 0.48–0.82 | 0.001 |
| DLCO, % predicted | 43.8 ± 12.56 | 62.4 ± 17.5 | 0.93 | 0.88–0.97 | 0.002 |
| Forced vital capacity, % predicted | 61.0 ± 20.99 | 74.6 ± 26.7 | 0.97 | 0.95–0.99 | 0.015 |
| PAP systolic, mmHg | 60.6 ± 15.09 | 53.1 ± 17.6 | 1.02 | 1.00–1.05 | 0.035 |
| Transpulmonary gradient, mmHg | 17.3 ± 7.10 | 13.5 ± 6.5 | 1.07 | 1.01–1.12 | 0.016 |
| Right atrial pressure, mmHg | 17.1 ± 7.04 | 12.3 ± 5.4 | 1.13 | 1.06–1.21 | < 0.001 |
| Multiple regression | |||||
| NT-pro BNP, 100 pg/mL | 1.06 | 1.03–1.10 | 0.001 | ||
| DLCO, % predicted | 0.94 | 0.89–1.00 | 0.021 |
Values are presented as mean ± standard deviations. CI: Confidence interval; NYHA: New York Heart Association, GFR: glomerular filtration rate, NT-pro BNP: N-terminal brain natriuretic peptide, DLCO: Diffusion capacity of the lung for carbon monoxide, PAP: pulmonary artery pressure