Figure 2.

Dilated Cardiomyopathy of PRMT1-cKO Mice

(A) Survival rate of control, heterozygous (fw/cre), and PRMT1-cKO mice.

(B and C) (B) Heart weight and (C) heart weight/body weight ratio (HW/BW) of 2-, 4-, and 6-week-old mice (n = 4–6).

(D) H&E and Masson's trichrome (MT) staining of the hearts at different ages.

(E) Cardiac contractility of control and PRMT1-cKO mice at different ages.

(F) Gene expression analysis for marker genes of cardiac dysfunction in the heart of 4-week-old control and PRMT1-cKO mice (n = 4).

All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared with age-matched control mice.