Fig. 8.

HOTAIR expression negatively correlated with miR-122 and positively correlated with CCNG1 in HCC.

(a–c) the statistically significant association between HOTAIR, miR-122 and CCNG1 expression in HCC specimens. (d–f) the expression of HOTAIR, CCNG1, DNMT1, DNMT3A, DNMT3B, and EZH2 in xenograft tumors were analyzed by qRT-PCR and WB. (g) the schematic overview of HOTAIR/miR-122 mediated tumorigenesis in HCC. Data are representative of three independent experiments and are presented as mean ± SD. *P < 0.05, **P < 0.01 (Student's t-test).