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. 2018 Sep 25;36:410–428. doi: 10.1016/j.ebiom.2018.08.048

Table 5.

Effects of social anxiety on thickness of cortical ROIs; heritability estimates.
Effect of (sub)clinical SADb
 Effect of social anxiety (z-score)b
 Effect of FNEb
 Heritability estimate
(Sub)clinical SADa No SADa β SE p β SE p β SE p h2 p
Superior frontal L 2.93 ± 0.17 2.93 ± 0.20 −0.07 0.04 0.07 −0.07 0.04 0.10 0.01 0.04 0.85 0.11 n.s.
R 2.92 ± 0.17 2.93 ± 0.20 −0.06 0.04 0.15 0.00 0.04 1.00 0.02 0.04 0.63 < 0.10 n.a.
Caudal middle frontal L 2.68 ± 0.16 2.65 ± 0.17 0.03 0.06 0.56 0.04 0.06 0.53 0.07 0.06 0.25 < 0.10 n.a.
R 2.66 ± 0.16 2.63 ± 0.17 0.05 0.06 0.44 0.03 0.06 0.60 −0.02 0.06 0.73 < 0.10 n.a.
Rostral middle frontal L 2.51 ± 0.17 2.51 ± 0.18 0.00 0.05 0.93 −0.04 0.05 0.41 0.06 0.05 0.26 < 0.10 n.a.
R 2.44 ± 0.17 2.48 ± 0.18 −0.13 0.05 0.02 ⁎ −0.12 0.05 0.03 ⁎ −0.08 0.05 0.15 < 0.10 n.a.
Lateral orbitofrontal L 2.80 ± 0.25 2.81 ± 0.20 −0.08 0.06 0.18 −0.06 0.05 0.28 −0.05 0.06 0.34 < 0.10 n.a.
R 2.71 ± 0.23 2.72 ± 0.22 −0.04 0.06 0.51 −0.02 0.05 0.71 −0.01 0.05 0.86 0.20 n.s.
Medial orbitofrontal L 2.60 ± 0.20 2.62 ± 0.21 −0.08 0.06 0.18 −0.12 0.06 0.04 ⁎ 0.06 0.06 0.32 0.48 0.035 ⁎
R 2.71 ± 0.28 2.67 ± 0.21 0.05 0.06 0.41 0.03 0.06 0.60 0.09 0.06 0.13 0.19 n.s.
Precentral L 2.61 ± 0.17 2.59 ± 0.15 −0.01 0.06 0.90 0.02 0.06 0.75 0.03 0.06 0.62 0.22 n.s.
R 2.59 ± 0.15 2.58 ± 0.16 −0.01 0.06 0.83 0.02 0.06 0.76 0.04 0.06 0.55 < 0.10 n.a.
Caudal anterior cingulate L 2.96 ± 0.25 2.91 ± 0.26 0.05 0.09 0.58 0.12 0.09 0.16 0.02 0.09 0.80 < 0.10 n.a.
R 2.72 ± 0.21 2.76 ± 0.25 −0.08 0.08 0.29 −0.15 0.08 0.06 −0.08 0.08 0.33 < 0.10 n.a.
Rostral anterior cingulate L 3.13 ± 0.26 3.08 ± 0.25 0.05 0.07 0.51 −0.04 0.07 0.60 0.14 0.07 0.05 ⁎ 0.48 0.024 ⁎
R 3.05 ± 0.25 3.15 ± 0.23 −0.18 0.08 0.02 ⁎ −0.07 0.08 0.36 0.09 0.08 0.27 0.48 0.016 ⁎⁎
Insula L 3.16 ± 0.20 3.17 ± 0.20 −0.05 0.06 0.44 −0.07 0.06 0.23 0.02 0.06 0.77 0.43 0.001 ⁎⁎
R 3.16 ± 0.21 3.15 ± 0.20 −0.01 0.07 0.93 −0.04 0.07 0.53 −0.06 0.07 0.38 0.29 0.046 ⁎
Superior parietal L 2.20 ± 0.14 2.19 ± 0.14 0.02 0.05 0.76 0.08 0.05 0.14 0.01 0.05 0.81 0.35 n.s.
R 2.17 ± 0.16 2.15 ± 0.15 0.07 0.05 0.19 0.02 0.05 0.68 −0.02 0.05 0.63 0.53 0.002 ⁎⁎
Inferior parietal L 2.53 ± 0.16 2.50 ± 0.16 0.08 0.05 0.11 −0.03 0.05 0.55 −0.03 0.05 0.52 0.35 n.s.
R 2.56 ± 0.14 2.52 ± 0.15 0.11 0.05 0.03 ⁎ 0.07 0.05 0.12 0.01 0.05 0.86 < 0.10 n.a.
Precuneus L 2.46 ± 0.21 2.44 ± 0.19 0.01 0.05 0.86 0.09 0.05 0.06 0.03 0.05 0.45 0.30 0.045 ⁎
R 2.45 ± 0.19 2.44 ± 0.20 −0.01 0.06 0.84 0.06 0.05 0.29 −0.06 0.05 0.28 < 0.10 n.a.
Supramarginal L 2.64 ± 0.17 2.58 ± 0.16 0.13 0.06 0.03 ⁎ 0.04 0.06 0.53 0.02 0.06 0.73 0.23 n.s.
R 2.62 ± 0.17 2.58 ± 0.17 0.06 0.06 0.32 0.08 0.06 0.14 0.12 0.06 0.04 ⁎ < 0.10 n.a.
Postcentral L 2.11 ± 0.18 2.09 ± 0.12 0.02 0.07 0.77 0.08 0.07 0.26 0.02 0.07 0.78 0.19 n.s.
R 2.03 ± 0.16 2.06 ± 0.13 −0.13 0.07 0.07 −0.03 0.07 0.66 −0.05 0.07 0.50 0.34 n.s.
Temporal pole L 3.63 ± 0.27 3.49 ± 0.28 0.25 0.09 0.01 ⁎ 0.07 0.09 0.48 0.14 0.10 0.15 0.11 n.s.
R 3.53 ± 0.36 3.50 ± 0.38 0.05 0.10 0.59 −0.02 0.09 0.85 −0.06 0.10 0.51 < 0.10 n.a.
Inferior temporal L 2.80 ± 0.14 2.77 ± 0.19 0.06 0.07 0.38 0.02 0.06 0.74 −0.06 0.07 0.33 < 0.10 n.a.
R 2.77 ± 0.15 2.78 ± 0.17 −0.05 0.07 0.47 0.01 0.07 0.89 −0.06 0.07 0.41 < 0.10 n.a.
Superior temporal L 2.84 ± 0.17 2.87 ± 0.19 −0.21 0.07 0.002 ⁎ −0.09 0.07 0.15 −0.08 0.06 0.21 0.74 7.5x10−5⁎⁎
R 2.89 ± 0.15 2.89 ± 0.17 −0.07 0.06 0.28 −0.05 0.06 0.39 −0.17 0.06 0.01 ⁎ 0.23 n.s.
Fusiform L 2.70 ± 0.16 2.71 ± 0.16 −0.06 0.06 0.34 −0.14 0.06 0.02 ⁎ −0.09 0.06 0.15 < 0.10 n.a.
R 2.69 ± 0.14 2.69 ± 0.17 0.00 0.06 0.97 0.02 0.06 0.69 0.07 0.06 0.26 < 0.10 n.a.
Transverse temporal L 2.46 ± 0.30 2.34 ± 0.27 0.15 0.07 0.04 ⁎ 0.09 0.07 0.22 0.03 0.07 0.66 0.64 1.7x10−6⁎⁎
R 2.49 ± 0.28 2.45 ± 0.33 0.02 0.08 0.83 0.01 0.08 0.89 0.03 0.08 0.72 0.47 0.001 ⁎⁎

FNE: fear of negative evaluation; L: left; n.a.: not applicable; n.s.: not significant; R: right; SAD: social anxiety disorder; SE: standard error.

Main effects of (sub)clinical SAD, social anxiety (z-score) and FNE are corrected for age (centered), gender, mean global cortical thickness (centered) and family-structure. Furthermore, the models including (sub)clinical SAD contained the interaction terms (sub)clinical SAD* age (centered) and (sub)clinical SAD* mean global cortical thickness (centered). Values of the covariates are reported in Supplementary Table 1. Reported p-values are uncorrected for multiple comparisons.

Main effects of (sub)clinical SAD, social anxiety (z-score) and FNE are corrected for age (centered), gender, mean global cortical thickness (centered) and family-structure. Furthermore, the models including (sub)clinical SAD contained the interaction terms (sub)clinical SAD*age (centered) and (sub)clinical SAD*mean global cortical thickness (centered). Values of the covariates are reported in Supplementary Table 1. Reported p-values are uncorrected for multiple comparisons.

a

Uncorrected mean ± standard deviation.

b

Coefficients represent standardized values.

⁎

Significant at uncorrected p-value of 0.05. ** Significant at FDR-corrected p-value.