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. 2018 Sep 25;36:410–428. doi: 10.1016/j.ebiom.2018.08.048

Table 6.

Effects of social anxiety on surface area of cortical ROIs; heritability estimates.

(Sub)clinical SADa No SADa Effect of (sub)clinical SADb
 Effect of social anxiety (z-score)b
 Effect of FNEb
 Heritability estimate
β SE p β SE p β SE p h2 p
Superior frontal L 7412.1 ± 884.9 7448.6 ± 809.4 0.09 0.05 0.07 0.01 0.05 0.91 −0.01 0.05 0.89 0.59 0.003 ⁎⁎
R 7112.2 ± 809.1 7268.8 ± 845.4 −0.04 0.05 0.44 0.00 0.05 0.94 0.07 0.05 0.15 0.48 0.001 ⁎⁎
Caudal middle frontal L 2416.5 ± 360.0 2398.2 ± 400.2 0.05 0.07 0.46 0.08 0.07 0.24 0.10 0.07 0.13 0.31 0.036 ⁎
R 2241.5 ± 371.9 2206.5 ± 355.9 0.07 0.07 0.36 0.02 0.07 0.83 0.01 0.07 0.90 0.54 0.057
Rostral middle frontal L 5947.1 ± 805.4 6080.3 ± 862.2 0.00 0.05 0.97 −0.02 0.05 0.59 0.00 0.04 0.97 0.66 2.7x10−4⁎⁎
R 6277.7 ± 924.3 6347.6 ± 934.5 0.04 0.04 0.33 0.00 0.04 0.92 −0.01 0.04 0.83 0.79 1.6x10−5⁎⁎
Lateral orbitofrontal L 2566.5 ± 215.2 2644.7 ± 287.5 0.03 0.06 0.56 0.08 0.06 0.16 −0.02 0.05 0.75 0.76 9.3x10−6⁎⁎
R 2569.0 ± 260.1 2596.0 ± 282.4 0.01 0.08 0.94 0.01 0.07 0.90 −0.12 0.07 0.09 < 0.10 n.a.
Medial orbitofrontal L 1913.4 ± 239.6 1942.0 ± 253.0 0.00 0.07 0.97 0.06 0.07 0.41 0.03 0.07 0.73 < 0.10 n.a.
R 1872.9 ± 205.4 1872.6 ± 195.2 0.04 0.08 0.61 0.06 0.07 0.45 0.06 0.07 0.41 < 0.10 n.a.
Precentral L 4821.7 ± 450.3 4887.3 ± 491.4 −0.04 0.06 0.54 0.02 0.06 0.77 0.05 0.06 0.45 0.26 0.035 ⁎
R 4924.3 ± 502.2 4925.0 ± 461.3 0.04 0.06 0.48 0.10 0.06 0.09 0.03 0.06 0.57 0.24 0.049 ⁎
Caudal anterior cingulate L 641.3 ± 120.6 678.0 ± 172.2 −0.05 0.08 0.54 0.06 0.08 0.43 −0.01 0.08 0.89 0.17 n.s.
R 819.9 ± 178.4 834.2 ± 150.3 −0.02 0.09 0.79 −0.05 0.08 0.51 −0.16 0.08 0.05⁎ 0.16 n.s.
Rostral anterior cingulate L 828.2 ± 161.3 850.7 ± 155.6 −0.01 0.07 0.93 0.05 0.07 0.50 −0.01 0.07 0.94 < 0.10 n.a.
R 673.7 ± 158.3 711.7 ± 117.4 −0.07 0.08 0.36 0.02 0.08 0.79 −0.06 0.08 0.42 0.44 0.002 ⁎⁎
Insula L 2277.4 ± 188.0 2275.6 ± 225.0 0.04 0.06 0.56 0.00 0.06 0.98 −0.04 0.06 0.47 0.49 0.004 ⁎⁎
R 2272.2 ± 271.2 2327.7 ± 262.0 −0.03 0.08 0.69 −0.08 0.07 0.30 0.06 0.07 0.39 0.45 0.002 ⁎⁎
Superior parietal L 5611.9 ± 584.8 5609.0 ± 693.8 0.00 0.06 0.99 0.04 0.06 0.54 0.00 0.06 0.99 0.39 0.029 ⁎
R 5620.2 ± 734.3 5631.8 ± 664.2 0.00 0.07 0.98 0.06 0.06 0.35 0.09 0.07 0.19 0.35 n.s.
Inferior parietal L 4751.4 ± 749.4 4880.4 ± 663.4 −0.02 0.06 0.78 −0.02 0.06 0.67 −0.01 0.05 0.78 < 0.10 n.a.
R 5618.7 ± 811.9 5843.9 ± 918.8 −0.10 0.06 0.06 −0.09 0.05 0.10 −0.04 0.06 0.43 0.17 n.s.
Precuneus L 3853.2 ± 504.3 3922.2 ± 504.2 0.00 0.05 0.94 0.02 0.05 0.73 0.02 0.05 0.66 0.47 2.4x10−5⁎⁎
R 4063.1 ± 527.7 4095.5 ± 534.8 0.04 0.06 0.48 0.03 0.06 0.65 0.13 0.06 0.02⁎ < 0.10 n.a.
Supramarginal L 3966.7 ± 608.7 4110.0 ± 664.4 −0.09 0.06 0.16 −0.01 0.06 0.85 −0.02 0.06 0.67 0.75 1.1x10−6⁎⁎
R 3895.4 ± 616.5 3922.6 ± 652.1 0.06 0.06 0.30 −0.03 0.06 0.62 −0.05 0.06 0.36 0.32 0.005 ⁎⁎
Postcentral L 4249.8 ± 634.9 4323.8 ± 511.6 −0.02 0.06 0.70 −0.03 0.06 0.60 −0.02 0.06 0.79 0.29 0.034 ⁎
R 4086.7 ± 597.0 4147.1 ± 536.8 −0.01 0.06 0.89 0.03 0.06 0.63 −0.06 0.06 0.35 0.22 0.049 ⁎
Temporal pole L 474.7 ± 59.4 484.3 ± 64.4 −0.05 0.09 0.56 0.03 0.08 0.74 −0.02 0.09 0.82 0.15 0.028 ⁎
R 403.2 ± 64.7 407.1 ± 52.8 0.01 0.09 0.93 0.02 0.09 0.80 0.02 0.09 0.82 0.34 0.005 ⁎⁎
Inferior temporal L 3544.0 ± 452.0 3583.9 ± 591.1 0.02 0.06 0.70 −0.02 0.06 0.75 −0.04 0.06 0.51 < 0.10 n.a.
R 3314.4 ± 508.7 3367.0 ± 490.0 0.01 0.05 0.91 −0.02 0.06 0.69 −0.02 0.05 0.70 0.38 0.004 ⁎⁎
Superior temporal L 3947.8 ± 457.5 3921.2 ± 476.2 0.06 0.06 0.30 0.04 0.06 0.49 0.07 0.05 0.20 0.92 5.8x10−6⁎⁎
R 3773.6 ± 407.2 3675.4 ± 315.8 0.08 0.05 0.15 0.00 0.05 0.96 0.06 0.05 0.26 0.75 3.8x10−4⁎⁎
Fusiform L 3405.1 ± 446.8 3371.7 ± 474.6 0.09 0.07 0.18 −0.08 0.07 0.22 0.01 0.06 0.92 0.34 0.004 ⁎⁎
R 3162.8 ± 408.3 3274.9 ± 451.4 −0.09 0.06 0.13 −0.12 0.05 0.02⁎ −0.04 0.05 0.47 0.33 3.6x10−6⁎⁎
Transverse temporal L 482.6 ± 75.0 495.4 ± 77.4 −0.03 0.08 0.71 −0.01 0.08 0.92 0.01 0.08 0.93 0.55 0.004 ⁎⁎
R 361.1 ± 57.5 368.8 ± 67.7 −0.02 0.08 0.79 0.02 0.08 0.84 0.03 0.08 0.72 0.52 0.002 ⁎⁎

FNE: fear of negative evaluation; L: left; n.a.: not applicable; n.s.: not significant; R: right; SAD: social anxiety disorder; SE: standard error.

Main effects of (sub)clinical SAD, social anxiety (z-score) and FNE are corrected for age (centered), gender, total global cortical surface area (centered) and family-structure. Furthermore, the models including (sub)clinical SAD contained the interaction terms (sub)clinical SAD* age (centered) and (sub)clinical SAD* total global cortical surface area (centered). Values of the covariates are reported in Supplementary Table 1.

Main effects of (sub)clinical SAD, social anxiety (z-score) and FNE are corrected for age (centered), gender, total global cortical surface area (centered) and family-structure. Furthermore, the models including (sub)clinical SAD contained the interaction terms (sub)clinical SAD*age (centered) and (sub)clinical SAD*total global cortical surface area (centered). Values of the covariates are reported in Supplementary Table 1.

Reported p-values are uncorrected for multiple comparisons.

a

Uncorrected mean ± standard deviation.

b

Coefficients represent standardized values.

⁎

Significant at uncorrected p-value of 0.05. ** Significant at FDR-corrected p-value.