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. 2017 Feb 28;19(3):237–249. doi: 10.1016/j.neo.2016.07.009

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cox-2 was overexpressed in tumor tissues and upregulated in M15 cell line after Wt1 knockdown.

Immunohistochemical analysis of control kidneys from mouse (2A) and tumors (2B) showed robust expression of inflammatory marker COX2 with minimal expression in tubules of the control kidneys (2A). This COX2 expression was similar to human normal kidneys (2C) and tumors (2D) respectively. RPPA analysis of mouse mesenchymal cells (M15) in which WT1 was knocked down revealed up regulation of COX-2 (2E) (marked with orange rectangular box). The expression of these genes in each compartment is visualized as heat map. Red indicates up-regulated genes and green indicates down-regulated genes.