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HIF 1 alpha and pERK1/2 expression in mouse and human tumors.
To demonstrate the activation of COX2 pathway, its downstream targets HIF-1 α and MAPK (p-ERK1/2) were evaluated by IHC. HIF-1α was overexpressed in mouse tumors (3B and 3C) compared to control kidneys (3A) and similar to human tumors (3E and 3F) and normal kidneys (3D) respectively. Similarly, MAPK (p-ERK1/2) expression in mouse tumors (Figs. 3G-I) was consistent with the human tumors (Figs. 3J-L).
