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. 2018 Oct 1;36:446–453. doi: 10.1016/j.ebiom.2018.09.025

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Post-hoc analyses of brain regions that overlapped in the Toronto and Replication samples. Regions of interest (ROIs) representing brain regions with the greatest amount of overlap between the Toronto and Replication samples were examined. ROIs were noted to be mainly related to the auditory (AUD), somatomotor (SMN), and default mode (DMN) networks. The mean functional connectivity within the auditory, somatomotor, and default mode networks was then calculated for each participant and included in a linear model for the Toronto and Replication samples with age, sex, years of education, and mean frame displacement as covariates. There was no significant (p < 0·05) difference between patients and controls within the DMN for the Toronto or Replication samples. However, both samples demonstrated significantly decreased within-network functional connectivity in patients for the SMN and AUD networks. In terms of between-network functional connectivity, the SMN to AUD, DMN to SMN, and DMN to AUD between-network functional connectivity was significantly decreased in patients in both the Toronto and Replication samples.