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. 2018 Oct 10;12(10):e0006867. doi: 10.1371/journal.pntd.0006867

Fig 5. A schematic representation of examples of detected modular structure in several treponemal genes.

Fig 5

A. The modular structure of TP0126/TP0126b and TP0126c genes (coordinates 148661–148691 and 149217–149247, respectively, according to the TPE Samoa D genome [6]). The TPE Fribourg-Blanc strain has identical sequences between regions where the TP0126 and TP0126b genes overlap and in TP0126c, while other analyzed genomes have different sequences in the TP0126/TP0126b. B. The modular structure of the TP0127b, TP0128, TP0130, and TP0898 genes (coordinates 150108–150120, 150605–150619, 151643–151659, and 977776–977789, respectively, according to the TPE Samoa D genome [6]). The TEN Bosnia A strain has identical sequences in regions of TP0128, TP0130, and TP0898 genes, while other genomes have the same sequences between regions of the TP0128 and TP0130 genes and between the TP0127b and TP0898 genes. C. The modular structure of the TP0117, TP0131, TP0316, and TP0620 genes (coordinates 134610–134655, 152056–152101, 331882–331927, and 672661–672706, respectively, according to the TPE Samoa D genome [6]). The TPE LMNP-1 strain has identical sequences in all of these genes while other genomes have the same sequences between regions of the TP0117 and TP0131 genes and between the TP0316 and TP0620 genes. D. The modular structure of the TP0117, TP0131, TP0316, and TP0620 genes (coordinates 134676–134672, 152122–152138, 331948–331964, and 672727–672743, respectively, according to the TPE Samoa D genome [6]). The TPE LMNP-1 and TEN Bosnia A strains have identical sequences in all of these genes while other genomes have the same sequences between regions of the TP0117 and TP0131 genes and between the TP0316 and TP0620 genes. E. The modular structure of the TP0117, TP0131, TP0316, and TP0620 genes (coordinates 134780–134804, 152226–152250, 332052–332076, and 672831–672855, respectively, according to the TPE Samoa D genome [6]). The TPE LMNP-1 strain has identical sequences in all these genes while TPE strains Gauthier, CDC 2575, and Ghana-051 have identical sequences between regions of the TP0117 and TP0131 genes and between the TP0316 and TP0620 genes. The remaining genomes have the same sequences between the TP0316 and TP0620 genes.