Fig. 2.

Epigenomic features of the KRAS subtypes.

(a) and (b) Volcano plot of the global DNA methylation difference (difference in β values) between the subtypes of patients (a) and cell lines (b). Probes hypermethylated in PS1 or CS1 are labeled in dark red (difference > 0.2, Q < 0.1), whereas probes hypermethylated in PS2 or CS2 are labeled in dark blue (difference < −0.2, Q < 0.1). Wilcoxon test, Q values are FDR-adjusted P values.

(c) and (d) Comparison of the smoking-related methylation signature among the three groups in patients (c) and cell lines (d) Wilcoxon test was used for the comparison.