Fig. S2.

(correlated with Fig. 1).

COX-2 IHC scoring in intestinal lamina propria and the quantified levels of PGF_2α and TxB₂ quantified by GC–MS analysis. (a, b) Scoring of the percentage of COX-2⁺ cells (a) and scoring of the staining intensity of COX-2⁺ cells (b) based on the IHC stains performed in lamina propria cells from Rs, PNRs (before and after TNF inhibitor treatment), and control subjects Rs, n = 10; PNRs, n = 10, and control subjects, n = 10. (c) Protein levels of PGF_2α were quantified by GC–MS analysis. Rs (n = 7), PNRs (n = 6), and control subjects (n = 6). (d) Protein levels of TxB₂ were quantified by GC–MS analysis. TxB₂ can be detected in five Rs (n = 7), four PNRs (n = 6), and control subjects (n = 6). (a–d) Data are shown as the median with interquartile ranges. The Kruskal-Walls test was used to compare the data. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns = no statistically significant difference.