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. 2018 Sep 28;16:350–360. doi: 10.1016/j.csbj.2018.09.003

Table 2.

Top NCI Standard Agents with similar activity profiles to 1 and 2.

Compound Vector correlation PCC Mechanism of action Cell lines
1 Maytansinea 0.554 Bind to tubulin & inhibit microtubule assembly [41] 41
1 Batracylinb 0.488 Dual inhibitor of DNA topoisomerases I/II [43] 43
2 Maytansinea 0.554 Bind to tubulin & inhibit microtubule [41] 41
2 D-tetrandrineb 0.488 Calcium channel blocker & anti-inflammatory [44,45] 54
a

High concentration tested: 10–8.6 M.

b

High concentration tested: 10–4.0 M.