Fig. 2.

Parasite load, inflammation markers, and liver function test (LFT) abnormalities.

A) Parasite load in CHMI without- (no LFT#), and with LFT abnormalities (LFT#). Error bars represent median with inter-quartile range. Parasite load as the area under the curve (AUC) represents the total parasite exposure over time. B) Association of parasite load and severity of liver function abnormalities in x the upper limit of normal of LFTs (xULN of LFTs) in CHMI subjects. C) C-reactive protein (CRP) levels of patients with imported uncomplicated P. falciparum malaria on admission day. D) Maximum d-dimer levels measured in participants with LFT abnormalities (LFT#) in CHMI. D-dimer data are from 6 CHMI studies (n = 81) with multiple samples measured during challenge infection. Error bars represent the median with inter-quartile range. ***p < 0.001.