Figure 4.
The Schematic Process of SS-PAA/DNA In Vitro and the Formation of Poly(PEG-co-(BMDO-co-DMAEMA)) with EtBr
(A) The concept of DNA condensation and subsequent intracellular release. (a) Formation of SS-PAAs/DNA polyplexes that are stable in the extracellular environment, (b) intracellular reduction of the disulfide linkages in the polymer of the polyplex, and (c) dissociation of DNA from the degraded polymer are shown. Reproduced with permission from Lin et al.94 Copyright © 2007 American Chemical Society. (B) Synthesis route for the formation of the poly(PEG-co-(BMDO-co-DMAEMA)) and poly(PEG-co-(BMDO-co-DMAEMA))·EtBr. Reproduced with permission Zhang et al.98 Copyright © 2012 American Chemical Society.