Figure 6.
The Schematic Process of AuNP-p(T)DNA and PLC-ZD55-IL-24
(A) Schematic showing the use of AuNP-p(T)DNA in enhancing the translation of different mRNA templates. Genes of interest were inserted separately into pcDNA6 plasmid vector containing BGH polyadenylation (P(A)) signal and transcribed to produce the respective mRNA templates with a poly(A) tail. AuNP-p(T)DNA was added to mRNA templates to allow hybridization between the poly(T) oligonucleotide on AuNP and the poly(A) tail on the mRNA, which facilitated the increased production of the respective proteins. Reproduced with permission from Chan et al.111 Copyright © 2018 American Chemical Society. (B) Synthetic route used to prepare PLC-ZD55-IL-24. Reproduced with permission from Chen et al.121 Copyright © 2016 American Chemical Society.