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Multifunctional Cationic Polymer for Preclinical Gene Delivery Systems
| Functionalization | Advantage |
|---|---|
| PEGylation | stabilization enhanced, circulation time improved, prevention of protein absorption |
| Targeting | gene target efficacy in vivo enhanced |
| Stimulus response | gene target efficacy in vivo enhanced |
| Cell penetrating | cellular uptake enhanced, cross cell membrane |
| Endosome escaping | endosomal escaping enhanced, cross cell membrane |
| Nuclear localization | nuclear localization |
