Table 2.
Baseline characteristics of the IBIS-3 sub-study population.
| IBIS-3 core: |
IBIS-3 sub-study: |
P Value | |
|---|---|---|---|
| (n = 164) | markers (n = 143) | ||
| Age (SD) | 59.8 (9.0) | 59.6 (9.0) | 0.44 |
| Gender (% men) | 138 (84.1) | 121 (84.6) | 0.67 |
| BMI* (SD) | 28.6 (4.4) | 28.8 (4.5) | 0.12 |
| Statin use (SD) | 156 (95.1) | 135 (94.4) | 0.60 |
| Cardiovascular risk factor (%) | |||
| Diabetes | 34 (20.7) | 28 (19.6) | 0.90 |
| Hypertension | 104 (64.2) | 89 (62.7) | 0.28 |
| Hypercholesterolemia ± | 103 (63.6) | 90 (63.4) | 0.89 |
| Current smoker | 46 (28.0) | 41 (28.7) | 0.64 |
| Family history of CAD± | 89 (54.6) | 76 (53.5) | 0.47 |
| Renal failure | 6 (3.7) | 5 (3.5) | 0.57 |
| History of cardiovascular disease (%) | |||
| MI | 49 (29.9) | 42 (29.4) | 0.71 |
| CABG | 1 (0.6) | 0 (0) | 0.13 |
| PCI | 59 (36.0) | 51 (35.7) | 0.83 |
| Stroke | 15 (9.1) | 14 (9.8) | 0.70 |
| Indication for coronary angiography (%) | |||
| STEMI | 24 (14.7) | 21 (14.7) | 0.44 |
| NSTE ACS | 44 (26.8) | 36 (25.2) | |
| Stable angina | 96 (58.5) | 86 (60.1) | |
| PCI performed (%) | 146 (89.0) | 128 (89.5) | 0.71 |
| Time between procedures (IQR, days) | 386 (372–404) | 386 (374–403) | 0.72 |
| Last used Rosuvastatin dose (IQR, mg) | 40 (20–40) | 40 (20–40) | 0.93 |
IBIS 3 core: patients with completed treatment phase and matching baseline and follow-up RF-IVUS; IBIS-3 substudy: patients with available blood samples for measuring oxLDL;
* missing in 10 patients (both cohorts); missing in 2 patients and one patient respectively; ± missing in 1 patient (both cohorts); RF-IVUS: radiofrequency intravascular ultrasound; oxLDL: oxidized low density lipoprotein; BMI: body mass index; CAD: coronary artery disease; MI: myocardial infarction; CABG: coronary artery bypass grafting; PCI: percutaneous coronary intervention; STEMI: ST-elevation myocardial infarction; NSTE ACS; non-ST-elevation acute coronary syndrome. P values derived from testing the differences between patients included in sub-cohort (n = 143) and those not included (n = 21), using Chi-square tests and Fisher's Exact tests for categorical variables and t-tests and Mann–Whitney U tests for normally and non-normally distributed continuous variables respectively.