Fig. 8.

AS clusters associated with prognosis and molecular subtypes. (a) Elbow and Gap statistic analysis for different numbers of clusters (k  =  2 to 8). (b) Consensus matrix heatmap defined four clusters of samples for which consensus values range from 0 (in white, samples never clustered together) to 1 (dark blue, samples always clustered together). (c) Heatmap of the 421 DEAS ordered by cluster, with annotations associated with each cluster, data analyzed using chi-squared test. (d) Kaplan-Meier survival analysis of patients within different clusters on both OS and DFS. Depicted P-values are from log-rank tests. (e) Spine plots of the relationship between molecular subtypes and MSI hypotype, AS cluster respectively. P-values are from Kruskal-Wallis tests.