Kaplan-Meier estimates of OS and DFS stratified by the Tumor, Node, Metastasis system and TNM stage in the TCGA CRC cohort. (a) Overall survival. (b) Disease-free survival. Local invasion stage(T1, T2, T3, T4), lymph node metastasis (N0, N1, N2), Distant metastasis (M0, M1); The differences between the two curves were determined by the two-sided log-rank test. Overall log-rank test, p-value <.0001.