Fig. 9.

pCR of a triple receptor negative breast cancer of a 51-year-old woman with a high-grade invasive ductal carcinoma treated with carboplatin and docetaxel every 3 weeks for six cycles. Left panel: US images obtained at pretreatment, at the end of cycle 1 (EOC1), 2(EOC2, not shown), 3 (EOC3), and before surgery. On US, the tumor manifest as an oval mass with well-defined margins, measuring 2.02 cm maximally before treatment, decreased mildly to 1.49 cm at the completion of cycle 1, but was unchanged in size from the end of cycle 2 to before surgery. Right panel: tHb maps obtained at the corresponding time points. Each map shows seven subimages marked as slices 1 to 7 and each subimage shows spatial $x$ and $y$ distribution ($9\mathrm{cm}\times 9\mathrm{cm}$) of tHb concentration reconstructed from 0.5 to 3.0 cm depth range from the skin surface. The spacing between the subimages in depth is 0.5 cm. The color bar is tHb in micromoles per liter. The tHb reduced from $83.3\mathrm{mol}/\mathrm{L}$ measured before treatment to 69.0, 55.3, and $37.9\mathrm{mol}/\mathrm{L}$ measured before completion of cycle 1, cycle 2, and cycle 3. A reduction of 17.2%, 33.6%, and 54.5% occurred at the end of cycle 1, 2, and 3, respectively. The hemoglobin level remains unchanged to the end of the treatment before surgery. This patient had a complete pathologic response with no residual tumor, MP grade 5.