Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 30;23(3):109–116. doi: 10.15430/JCP.2018.23.3.109

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Korean Society of Cancer Prevention

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Signaling pathways involving PIM kinase. Up-stream target proteins of PIM (proviral integration site for moloney murine leukemia virus) kinase are janus kinase/signal transducers and activators of transcriptions (JAK/STATs) and their activations cause to stimulate PIM kinase. Activated PIM kinase boosts its downstream signaling targets, such as myelocytomatosis (MYC), BCL-2-associated agonist of cell death (BAD), p21^Cip1/Waf1/p27^Kip1, and cell devision cycle 25 (CDC25), and regulates gene transcription, cell cycle progression, and apoptosis.