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. 2018 Oct 22;13(10):e0205524. doi: 10.1371/journal.pone.0205524

Table 3. Association between physician sex and initial cholinesterase inhibitor dose prescribed.

Groups Physician Sex Unadjusted Patient adjusted*
Lower-than-Recommended initial dose** Higher-than- Recommended initial dose** Lower-than-Recommended initial dose** Higher-than- Recommended initial dose**
OR (95% CI) P-value OR (95% CI) P-value AOR (95% CI) P-value AOR (95% CI) P-value
Overall Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 1.43
(1.17–1.74)
0.0004 0.90
(0.78–1.03)
0.1369 1.34
(1.08–1.65)
0.0068 0.89
(0.77–1.03)
0.1211
Family Medicine/General practice Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 1.33
(1.07–1.64)
0.0087 0.91
(0.79–1.04)
0.1775 1.31
(1.06–1.62)
0.0121 0.93
(0.80–1.07)
0.2847
Dementia Specialist (Geriatric Medicine, Psychiatry, Neurology) Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 3.81
(2.54–5.72)
< .0001 0.76
(0.53–1.08)
0.1198 3.68
(2.47–5.49)
< .0001 0.78
(0.55–1.10)
0.1572
 Geriatric Medicine Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 2.84
(1.45–5.56)
0.0023 1.29
(0.83–2.00)
0.2587 2.76
(1.39–5.51)
0.0039 1.33
(0.85–2.09)
0.2087
 Psychiatry Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 3.17
(1.58–6.37)
0.0012 0.58
(0.34–0.98)
0.0427 3.00
(1.48–6.08)
0.0023 0.60
(0.36–0.99)
0.0440
 Neurology Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 3.27
(1.76–6.06)
0.0002 1.14
(0.57–2.28)
0.7168 3.25
(1.73–6.11)
0.0003 1.17
(0.58–2.35)
0.6593
Non Dementia Specialist Male 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
Female 1.34
(0.74–2.45)
0.3355 1.05
(0.64–1.72)
0.8366 1.27
(0.69–2.34)
0.4358 1.02
(0.62–1.67)
0.9400

*Adjusted for patient age (continuous), sex, income quintile, rural residence, number of ADGs (continuous), acute myocardial infarction, asthma, angina, arrhythmia, cancer, diabetes, congestive heart failure, hypertension, stroke, liver disease, renal disease, mood/anxiety disorders, and number of concurrent medications used.

** Compared to recommended initial dose

ref: reference category.