Table 1.
Clinical characteristics of the patients by ADRB2 Arg16Gly A > G genotype
| Characteristics | All patients | Patients with AA genotype | Patients with AG genotype | Patients with GG genotype | P valuea |
|---|---|---|---|---|---|
| (N = 2403) | (N = 923) | (N = 1122) | (N = 358) | ||
| Age (years) | 59.3 ± 14.5 | 58.7 ± 14.5 | 59.0 ± 14.6 | 59.8 ± 14.5 | 0.208 |
| Male sexb | 1601 (66.6) | 616 (66.7) | 752 (67.0) | 233 (65.1) | 0.791 |
| Ischemic etiologyb | 1137 (47.3) | 450 (48.8) | 525 (46.8) | 162 (45.3) | 0.343 |
| NYHA functional classb | |||||
| II | 1042 (43.4) | 417 (45.2) | 479 (42.7) | 146 (40.8) | |
| III | 812 (33.8) | 316 (34.2) | 379 (33.8) | 117 (32.7) | 0.201 |
| IV | 549 (22.8) | 190 (20.6) | 264 (23.5) | 95 (26.5) | |
| Personal historyb | |||||
| Smoking | 937 (39.0) | 365 (39.5) | 436 (38.9) | 136 (38.0) | 0.87 |
| Hypertension | 2103 (87.5) | 779 (84.4) | 1005 (89.6) | 309 (89.1) | <0.001 |
| Hyperlipidemia | 597 (24.8) | 241 (26.1) | 265 (23.6) | 91 (25.4) | 0.415 |
| Diabetes | 765 (31.8) | 290 (31.4) | 353 (31.5) | 122 (34.1) | 0.614 |
| Stroke | 246 (10.2) | 102 (11.1) | 113 (10.1) | 31 (8.7) | 0.434 |
| Clinical testing | |||||
| Systolic pressure (mm Hg) | 131.2 ± 25.2 | 131.8 ± 25.2 | 129.0 ± 24.2 | 131.3 ± 25.5 | 0.243 |
| Diastolic pressure (mm Hg) | 80.3 ± 16.2 | 80.7 ± 16.8 | 78.6 ± 14.4 | 80.5 ± 16.2 | 0.1 |
| Heart rate (beats/min) | 83.2 ± 20.2 | 82.7 ± 20.0 | 83.5 ± 20.0 | 83.6 ± 20.4 | 0.573 |
| Serum creatinine (µmol/l)c | 84 (67–106) | 82 (66–105) | 84 (69–107) | 84 (66–107) | 0.232 |
| NT-proBNP (pg/ml)c | 1857(424–5652) | 1859 (514–5013) | 1774 (405–5706) | 2131 (351–6962) | 0.435 |
| LVEDD (mm)c | 55 (48–64) | 54 (47–63) | 55 (48–64) | 56 (47–64) | 0.152 |
| LAD (mm)c | 40 (35–45) | 39 (34–45) | 40 (35–45) | 40 (36–46) | 0.2 |
| Ejection fraction (%)c | 47 (33–61) | 48 (33–62) | 47 (32–60) | 44 (32–61) | 0.334 |
| Medication (%) | |||||
| Digoxin | 563 (23.6) | 214 (23.3) | 274 (24.6) | 75 (21.1) | 0.382 |
| Diuretics | 1104 (46.3) | 402 (43.7) | 527 (47.4) | 175 (49.3) | 0.121 |
| ACEI | 1246 (52.2) | 466 (50.7) | 584 (52.5) | 196 (55.2) | 0.340 |
| ARB | 279 (11.7) | 102 (11.1) | 142 (12.8) | 35 (9.9) | 0.257 |
| Beta-blocker | 1365 (57.2) | 534 (58.1) | 636 (57.2) | 195 (54.9) | 0.590 |
| Spironolactone | 938 (39.3) | 354 (38.5) | 437 (39.3) | 147 (41.4) | 0.639 |
ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blockers, LAD left atrial dimension, LVEDD left ventricular end-diastolic dimension, NT-proBNP the N-terminal pro-hormone of brain natriuretic peptide, NYHA New York Heart Association
aFor similarity among the different genotypes
bListed as number (%)
cInterquartile range included in parentheses