Figure 1.

The transcriptome of pediatric IBD patients varies according to disease subtype and tissue profiled. (A) Barplot depicting (in log-scale) the amount of variance in gene expression explained by tissue, disease subtype, and the interaction among both along with the residual. (B) Heatmap showing the total number of differentially expressed genes in each pairwise comparison as detected by edgeR (see Supplementary Materials and Methods section). Top diagonal (in red colors) shows genes up-regulated and the bottom diagonal (in blue background) shows genes down-regulated, with the reference group included in parenthesis at the bottom of each cell.